脳神経外科 - 英語論文

  1. Ryohei Otani, Masachika Ikegami, Ryoji Yamada, Hirohisa Yajima, Shinji Kawamura, Sakura Shimizu, Shota Tanaka, Shunsaku Takayanagi, Hirokazu Takami, Tatsuro Yamaguchi . PTPN11 variant may be a prognostic indicator of IDH-wildtype glioblastoma in a comprehensive genomic profiling cohort. J Neurooncol.Aug;164(1):221-229. 2023

  2. Ryohei Otani, Daichi Sadato, Ryoji Yamada, Hirohisa Yajima, Shinji Kawamura, Sakura Shimizu, Shota Tanaka, Shunsaku Takayanagi, Hirokazu Takami, Tatsuro Yamaguchi . CHD5 gene variant predicts leptomeningeal metastasis after surgical resection of brain metastases of breast cancer. J Neurooncol. Jul;163(3):657-662. 2023

  3. Taichi Tamura, Masachika Ikegami, Yusuke Kanemasa, Makiko Yomota, Akiko Furusawa, Ryohei Otani, Chiaki Saita, Ichiro Yonese, Tomoko Onishi, Hiroshi Kobayashi, Toru Akiyama, Tatsu Shimoyama, Tomoyuki Aruga, Tatsuro Yamaguchi. Selection bias due to delayed comprehensive genomic profiling in Japan. Cancer Sci. Mar;114(3):1015-1025. 2023

  4. Otani R, Mukasa A, Uzuka T, Higuchi F, Matsuda H, Nomura M, Tanaka S, Kim P, Ueki K.. Gene expression profiling of 19q-loss astrocytomas suggest a specific pattern associated with the better prognosis. J Neurooncol. Sep 154(2):221-228. 2021
  5. Kawaguchi K, Otani R, Kikuchi M, Kushihara Y, Funata N, Yamada R, Shinoura N.. Genetic Characteristics of Mismatch Repair-deficient Glioblastoma. NMC Case Report Journal 8, 565–571, 2021
  6. Otani R, Yamada R, Kawaguchi K, Kikuchi M, Kushihara Y, Shinoura N.. Utility of monitoring the serum levetiracetam concentration for intraoperative seizure control during awake craniotomy. Journal of Clinical Neuroscience 89, 279–282. 2021
  7. Otani R, Yamada R, Kushihara Y, Inazuka M, Shinoura N.. Continuous intrathecal injection therapy of methotrexate is a therapeutic option in primary CNS lymphoma. J Clin Neurosci. Nov; 69:26-30, 2019
  8. Shinoura N, Midorikawa A, Hiromitsu K, Saito S, Yamada R.Preservation of cranial nerve function following awake surgery for benign brain tumors in 22 consecutive patients. J Clin Neurosci. Mar; 61:189-195. 2019
  9. Otani R, Uzuka T, Matsuda H, Higuchi F, Kim P, Ueki K. Brain invasion by chronic lymphocytic leukemia. Neuropathology.Feb;39(1):54-57, 2019
  10. Hiromitsu K, Asai T, Saito S, Shigemune Y, Hamamoto K, Shinoura N, Yamada R, Midorikawa A.Measuring the sense of self in brain-damaged patients: A STROBE-compliant article. Medicine (Baltimore). Sep;97(36):e12156. 2018
  11. Otani R, Uzuka T, Higuchi F, Matsuda H, Nomura M, Tanaka S, Mukasa A, Ichimura K, Kim P, Ueki K. IDH-mutated astrocytomas with 19q-loss constitute a subgroup that confers better prognosis. Cancer Sci. 2018 Jul;109(7):2327-2335.
  12. Otani R, Mukasa A, Shin M, Omata M, Takayanagi S, Tanaka S, Ueki K, Saito N. Brachyury gene copy number gain and activation of the PI3K/Akt pathway: association with upregulation of oncogenic Brachyury expression in skull base chordoma. J Neurosurg. May;128(5):1428-1437, 2018.
  13. Wakabayashi T, Natsume A, Mizusawa J, Katayama H, Fukuda H, Sumi M, Nishikawa R, Narita Y, Muragaki Y, Maruyama T, Ito T, Beppu T, Nakamura H, Kayama T, Sato S, Nagane M, Mishima K, Nakasu Y, Kurisu K, Yamasaki F, Sugiyama K, Onishi T, Iwadate Y, Terasaki M, Kobayashi H, Matsumura A, Ishikawa E, Sasaki H, Mukasa A, Matsuo T, Hirano H, Kumabe T, Shinoura N, Hashimoto N, Aoki T, Asai A, Abe T, Yoshino A, Arakawa Y, Asano K, Yoshimoto K, Shibui S; Members of Japan Clinical Oncology Group Brain Tumor Study Group (JCOG-BTSG). JCOG0911 INTEGRA study: a randomized screening phase II trial of interferonβ plus temozolomide in comparison with temozolomide alone for newly diagnosed glioblastoma. J Neurooncol. 2018 Mar 20. doi: 10.1007/s11060-018-2831-7. [Epub ahead of print]
  14. Funata N, Nobusawa S, Nakata S, Yamazaki T, Takabagake K, KoikeT, Maegawa T, Yamada R, Shinoura N, Mine Y. A case report of adult cerebellar high-grade glioma with H3.1 K27M mutation: a rare example of an H3 K27M mutant cerebellar tumor. Brain Tumor Pathol. 2018 Jan;35(1):29-35. doi: 10.1007/s10014-017-0305-9. Epub 2017 Dec 20.
  15. Shinoura N, Midorikawa A, Hiromitsu K, Saito S, Yamada R. Preservation of hearing following awake surgery via the retrosigmoid approach for vestibular schwannomas in eight consecutive patients. Acta Neurochir (Wien). 159(9),1579-1585, 2017
  16. Shinoura N, Midorikawa A, Yamada R, Hiromitsu K, Itoi C, Saito S, Yagi K. Operative strategies during awake surgery affect deterioration of paresis one month after surgery for brain lesions in the primary motor area. Neurol Surg A Cent Eur Neurosurg. 78(4), 368-373, 2017.
  17. Otani R, Uzuka T, Ueki K. Classification of adult diffuse gliomas by molecular markers-a short review with historical footnote. Jpn J Clin Oncol. Jan;47(1):2-6, 2017
  18. Funata N, Nobusawa S, Yamada R, Shinoura N. A case of osteoclast-like giant cell-rich epithelioid glioblastoma with BRAF V600E mutation. Brain Tumor Pathol. 33(1), 57-62, 2016. 
  19. Itoi C, Hiromitsu K, Saito S, Yamada R, Shinoura N, Midorikawa A. Predicting sleepiness during an awake craniotomy. Clin Neurol Neurosurg. 139,307-10, 2015
  20. Shinoura N, Yamada R, Hatori K, Sato H, Kimura K. Stress hormone levels in awake craniotomy and craniotomy under general anesthesia. J Neurol Neurophysiol 5(6), 1-5, 2014.
  21. Shinoura N, Onodera T, Yamada R, Itoi C, Saito S, Midorikawa A, Yagi K. Awake sugery based on tractography for the removal of brain tumors located within the deep area of the left temporal lobe. Int J CARS 9(Suppl 1), S327, 2014.
  22. Suzuki Y, Yamaguchi T, Matsumoto H, Nakano D, Honda G, Shinoura N, Karasawa K, Takahashi K. Prognostic factors and treatment effects in patients with curatively resected brain metastasis from colorectal cancer. Dis Colon Rectum 57(1), 56-63, 2014
  23. Saito K, Mukasa A, Narita Y, Tabei Y, Shinoura N, Shibui S, Saito N. Toxicity and Outcome of Radiotherapy with Concomitant and Adjuvant Temozolomide in Elderly Patients with Glioblastoma: A Retrospective Study.Neurol Med Chir (Tokyo). 2013 Nov 20.
  24. Shinoura N, Midorikawa A, Yamada R, Hana T, Saito A, Hiromitsu K, Itoi C, Saito S, Yagi K. Awake craniotomy for brain lesions within and near the primary motor area: A retrospective analysis of factors associated with worsened paresis in 102 consecutive patients.Surg Neurol Int. 2013 Nov 22;4:149
  25. Shinoura N, Midorikawa A, T Onodera, M Tsukada, Yamada R, Tabei Y, Shiode T, Itoi C, Saito S, K Yagi. Damage to the left ventral, arcuate fasciculus and superior longitudinal fasciculus-related pathways induces deficits in object naming, phonological language function and writing, respectively. Int J Neurosci 123(7), 494-502, 2013.
  26. Otani R, Fukuhara N, Ochi T, Oyama K, Yamada S. Rapid growth hormone measurement during transsphenoidal surgery: analysis of 252 acromegalic patients. Neurol Med Chir (Tokyo). 52: 558-62, 2012
  27. Nagane M, Nishikawa R, Narita Y, Kobayashi H, Takano S, Shinoura N, Aoki T, Sugiyama K, Kuratsu J, Muragaki Y, Sawamura Y, Matsutani M. Phase II Study of Single-agent Bevacizumab in Japanese Patients with Recurrent Malignant Glioma. Jpn J Clin Oncol. 42, 887-95, 2012.
  28. Shinoura N, Midorikawa A, T Onodera, Yamada R, Tabei Y, Onda Y, Itoi C, Saito S, Yagi K. The left superior longitudinal fasciculus within the primary sensory area of inferior parietal lobe plays a role in dysgraphia of kana omission in the sentence. Behav neurol 25, 363-8, 2012.
  29. Shinoura N, Yamada R, Tabei Y, Otani R, Itoi C, Saito S, Midorikawa A. Damage to the right dorsal anterior cingulate cortex induces panic disorder. J Affect Disorders 133, 569-72, 2011.
  30. Shinoura N, Midorikawa A, Kurokawa K, Onodera T, Tsukada M, Yamada R, Tabei Y, Koizumi T, Yoshida M, Saito S, Yagi K. Right temporal lobe plays a role in verbal memory. Neurol Res 33, 734-8, 2011.
  31. Shinoura N, Yamada R, Tabei Y,Otani R, Itoi C, Saito S, Midorikawa A. Left or right temporal lesion might induce aggression or escape during awake surgery: role of the amygdale. Acta Neuropsychiatrica 23(7), 119-24, 2011.
  32. Shinoura N, Yamada R, Tabei Y, Saito K, Suzuki Y, Yagi K. Advantages and disadvantages of awake surgery for brain tumors in the primary motor cortex: institutional experience and review of literature. Br J Neurosurg 25, 218-24, 2011.
  33. Shinoura N, Onodera T, Kurokawa K, Tsukada M, Yamada R, Tabei Y, Koizumi T, Yagi K. Damage to the upper portion of area 19 and the deep white matter in the left inferior parietal lobe, including the superior longitudinal fasciculus, results in alexia with agraphia Eur Neurol 64, 224-9, 2010.
  34. Shinoura N, Suzuki Y, Yamada R, Tabei Y, Saito K, Yagi K. Relationships between brain tumor and optic tract or calcarine fissure are involved in visual field deficits after surgery for brain tumor. Acta neurochirurugica 152, 637-42, 2010.
  35. Shinoura N, Onodera T, Kurokawa K, Tsukada M, Yamada R, Tabei Y, Koizumi T, Yagi K. Damage of left temporal lobe resulting in conversion of speech to Sutra, a Buddhist prayer stored in the right hemisphere Neurocase 16, 317-20, 2010.
  36. Shinoura N, Suzuki Y, Tsukada M, Yamada R, Tabei Y, Koizumi T, Yagi K. Damage of white matter in the parietal lobe results in anomic alexia of kana. Can J Neurol Sci 37, 113-7, 2010.
  37. Shinoura N, Suzuki Y, Yamada R, Tabei Y, Takahashi M, Yagi K. Combined movement of multi-joint muscles activates a smaller area compared to the sum of areas activated by respective single-joint muscles after restoration of paresis. Neurocase 16, 175-81, 2010.
  38. Shinoura N, Suzuki Y, Tsukada M, Yoshida M, Yamada R, Tabei Y, Saito K, Koizumi T, Yagi K. Deficits in the left inferior longitudinal fasciculus results in impairments in object naming. Neurocase 16, 135-9, 2010.
  39. Shinoura N, Yoshida M, Yamada R, Tabei Y, Saito K, Suzuki Y, Yagi K. Combined damage to the right hemispheric hand area in the primary motor and sensory area plays a critical role in motor hemineglect. Eur Neurol 63, 17-23, 2010.
  40. Suzuki Y, Yagi K, Kodama T, Shinoura N. Corticospinal tract extraction combining diffuse tensor tractography with fMRI in patients with brain diseases. Magn Reson Med Sci 8, 9-16, 2009.
  41. Shinoura N, Suzuki Y, Yamada R, Tabei Y, Saito K, Yagi K. Damage to the right superior longitudinal fasciculus in the inferior parietal lobe plays a role in spatial neglect. Neuropsychologia 47, 2600-3, 2009.
  42. Shinoura N, Suzuki Y, Yamada R, Tabei Y, Saito K, Yagi K. Marked and rapid recovery of motor strength in premotor area compared with primary motor area in surgery for brain tumors. Br J Neurosurg 23, 309-14, 2009.
  43. Shinoura N, Suzuki Y, Yamada R, Tabei Y, Saito K, Yagi K. Precentral knob corresponds to the primary motor and premotor area. Can J Neurol Sci 36, 227-33, 2009.
  44. Shinoura N, Suzuki Y, Yoshida M, Yamada R, Tabei Y, Saito K, Yagi K. Assessment of the corona radiata sensory tract with awake surgery and tractography. J Clin Neurosci 16, 764-70, 2009.
  45. Shinoura N, Yoshida M, Yamada R, Tabei Y, Saito K, Suzuki Y, Takayama Y, Yagi K. Awake surgery with continuous task for resection of brain tumors in the primary motor area. J Clin Neurosci 16, 188-94, 2009.
  46. Shinoura N, Yamada R, Tabei Y, Saito K. Resolution of severe cervicogenic headache after cervical open-door laminoplasty Spinal Surgery 22, 90-5, 2008.
  47. Shinoura N, Tabei Y, Yamada R, Saito K, Takahashi M. Continuous intrathecal treatment with methotrexate via subcutaneous port: implication for leptomeningeal dissemination of malignant tumors. J Neurooncol 87, 309-16, 2008.
  48. Shinoura N, Suzuki Y, Watanabe Y, Yamada R, Tabei Y, Saito K, Yagi K. Mirror therapy activates outside of cerebellum and ipsilateral M1. Neurorehabilitation 23, 245-52, 2008.
  49. Takahashi M, Yamada R, Tabei Y, Nakamura O, Shinoura N. Navigation-guided Ommaya reservoir placement; implication for the treatment of leptomeningeal metastases. Minim Invasive Neurosurg 50, 340-5, 2007.
  50. Shinoura N, Suzuki Y, Watanabe Y, Yamada R, Tabei Y, Saito K, Yagi K. Mirror therapy activates outside of cerebellum and ipsilateral M1. Neurorehabilitation 2008 in press.
  51. Shinoura N, Suzuki Y, Yamada R, Tabei Y, Takahashi M, Yagi K. Combined movement of multi-joint muscles activates a smaller area compared to the sum of areas activated by respective single-joint muscles after restoration of paresis. Neurocase 2008 in press.
  52. Shinoura N, Suzuki Y, Tsukada M, Katsuki S, Yamada R, Tabei Y, Saito K, Yagi K. Impairment of inferior longitudinal fasciculus plays a role in visual memory disturbance. Neurocase 13, 127-30, 2007.
  53. Shinoura N, Yamada R, Suzuki Y, Kodama T, Sekiguchi K, Takahashi M, Yagi K. fMRI is more reliable than SEP or mapping for the detection of M1 in proximity to a tumor. Stereotact Funct Neurosurg 85, 99-105, 2007.
  54. Shinoura N, Yamada R, Takahashi M, Nakamura O. Use of 99mTc-MIBI SPECT for characterization of metastatic brain tumors: implications for surgery. Clin Nucl Med 31, 538-40, 2006.
  55. Shinoura N, Takahashi M, Yamada R. Intraoperative sononavigation and ultrasonography characterizes three types of brain tumors: implications for tumor resection. J Clin Ultrasound 34, 177-183, 2006.
  56. Shinoura N, Suzuki Y, Yamada R, Kodama T, Takahashi M, Yagi K. Restored activation of primary motor area from motor reorganization and improved motor function after brain tumor resection. AJNR Am J Neuroradiol 2006 in press.
  57. Shinoura N, Yamada R, Kodama T, Suzuki Y, Takahashi M, Yagi K. Association of motor deficits with head position during awake surgery for resection of medial motor area brain tumors. Minim Invasive Neurosurg 48, 315-321, 2005.
  58. Shinoura N, Takahashi M, Yamada R. Accurate characterization of the main trunk of the anterior cerebral artery using intraoperative sononavigation with ultrasound Doppler: Implication for brain tumor surgery. J Ultrasound Med 24, 1527-32, 2005.
  59. Shinoura N, Yamada R, Kodama T, Suzuki Y, Takahashi M, Yagi K. Intraoperative cortical mapping has low sensitivity for the detection of motor function in proximity to a tumor in the primary motor area. Stereotact Funct Neurosurg 83, 135-141, 2005.
  60. Shinoura N, Yamada R. Head-down manoeuvre in patients with a high symptom score for orthostatic intolerance reveals impaired right brain frontal lobe vasoreactivity Clin Neurophys 116, 1286-1290, 2005.
  61. Shinoura N, Yamada R. Decreased vasoreactivity to right cerebral hemisphere pressure in migraine without aura: a near-infrared spectroscopy study. Clin Neurophys 116, 1280-1285, 2005.
  62. Shinoura N, Suzuki Y, Yamada R, Kodama T, Takahashi M, Yagi K. Fibers connecting the primary motor and sensory area play a role in grasp stability of the hand. Neuroimage 25, 936-41, 2005.
  63. Shinoura N, Yamada R, Kodama T, Suzuki Y, Takahashi M, Yagi K. Preoperative fmri, tractography and continuous task during awake surgery for maintenance of motor function following surgical resection of metastatic tumor spread to the primary motor area. Minim Invasive Neurosurg 48, 85-90, 2005.
  64. Shinoura N, Yamada R. Dizziness is associated with decreased vasoreactivity in right cerebral hemisphere for head-down maneuver – near-infrated spectroscopy study. Clin Physiol Funct Imaging 25, 16-19, 2005.
  65. Shinoura N, Yamada R, Okamoto K, Nakamura O. Early prediction of infection after craniotomy for brain tumours. Br J Neurosurg 18, 598-603, 2004.
  66. Niibe Y, Karasawa K, Nakamura O, Shinoura N, Okamoto K, Yamada R, Fukino K, Tanaka Y. Survival benefit of stereotactic radiosurgery for metastatic brain tumors in patients with controlled primary lesions and no other distant metastases. Anticancer Res 23, 4157-4159, 2003.
  67. Uchida H, Shinoura N, Kitayama J, Watanabe T, Nagawa H, Hamada H. 5-Fluorouracil efficiently enhanced apoptosis induced by adenovirus-mediated transfer of caspase-8 in DLD-1 colon cancer cells. J Gene Med 5, 287-299, 2003.
  68. Shinoura N, Hamada H. Gene therapy using an adenovirus vector for apoptosis-related genes is a highly effective therapeutic modality for killing glioma cells. Curr Gene Ther 3, 147-153, 2003.
  69. Shinoura N, Yamada R, Okamoto K, Nakamura O, Shitara N. Local recurrence of metastatic brain tumor after stereotactic radiosurgery or surgery plus radiation. J Neurooncol 60, 71-77, 2002.
  70. Sakurai S, Sonoda Y, Koguchi E, Shinoura N, Hamada H, Kasahara T. Mutated focal adhesion kinase induces apoptosis in a human glioma cell line, T98G. Biochem Biophys Res Commun 293, 174-181, 2002.
  71. Uchida H, Shinoura N, Kitayama J, Watanabe T, Nagawa H, Hamada H. Caspase-8 gene transduction augments radiation-induced apoptosis in DLD-1 cells. Biochem Biophys Res Commun 292, 347-354, 2002.
  72. Shinoura N, Sakurai S, Shibasaki F, Asai A, Kirino T, Hamada H. Co-transduction of Apaf-1 and caspase-9 highly enhances p53-mediated apoptosis in gliomas. Br J Cancer 86, 587-595, 2002.
  73. Shinoura N, Furitsu T, Asai A, Kirino T, Hamada H. Co-transduction of p27Kip1 strongly augments Fas ligand- and caspase-8-mediated apoptosis in U-373MG glioma cells. Anticancer Res 21, 587-595, 2001.
  74. Shinoura N, Sakurai S, Asai A, Kirino T, Hamada H. Caspase-9 transduction overrides the resistance mechanism against p53-mediated apoptosis in U-87MG glioma cells. Neurosurgery 49, 177-186, 2001.
  75. Shinoura N, Sakurai S, Asai A, Kirino T, Hamada H. Over-expression of APAF-1 and caspase-9 augments radiation-induced apoptosis in U-373MG glioma cells. Int J Cancer 93, 252-261, 2001.
  76. Okamoto K, Shinoura N, Egawa N, Asai A, Kirino T, Shibasaki F, Shitara N. Adenovirus-mediated transfer of p53 augments hyperthermia-induced apoptosis in U251 glioma cells. Int J Radiat Oncol Biol Phys 50, 525-531, 2001.
  77. Shinoura N, Sakurai S, Asai A, Kirino T, Hamada H. Co-transduction of Apaf-1 and caspase-9 augments etoposide-induced apoptosis in U-373MG glioma cells. Jpn J Cancer Res 92, 467-474, 2001.
  78. Shinoura N, Muramatsu Y, Asai A, Han S, Horii A, Kirino T, Hamada H. Degree of apoptosis induced by adenovirus-mediated transduction of p53 and p73alpha depends on the p53 status of glioma cells. Cancer Lett 160, 67-73, 2000.
  79. Shinoura N, Yamamoto N, Asai A, Kirino T, Hamada H. Adenovirus-mediated transfer of Fas ligand gene augments radiation-induced apoptosis in U-373MG glioma cells. Jpn J Cancer Res 91, 1044-1050, 2000.
  80. Shinoura N, Sakurai S, Asai A, Kirino T, Hamada H. Transduction of a fiber-mutant adenovirus for the HSVtk gene highly augments the cytopathic effect towards gliomas. Jpn J Cancer Res 91, 1028-1034, 2000.
  81. Shinoura N, Sakurai S, Asai A, Kirino T, Hamada H. Transduction of Apaf-1 and caspase-9 induces apoptosis in A-172 cells that are resistant to p53-mediated apoptosis. Biochem Biophys Res Commun 272, 667-673, 2000.
  82. Shinoura N, Koike H, Furitu T, Hashimoto M, Asai A, Kirino T, Hamada H. Adenovirus-mediated transfer of caspase-8 augments cell death in gliomas: implications for gene therapy. Hum Gene Ther 11, 1123-1137, 2000.
  83. Shinoura N, Saito K, Yoshida Y, Hashimoto M, Asai A, Kirino T, Hamada H. Adenovirus-mediated transfer of bax with caspase-8 controlled by myelin basic protein promoter exerts an enhanced cytotoxic effect in gliomas. Cancer Gene Ther 7, 739-748, 2000.
  84. Shinoura N, Yoshida Y, Asai A, Kirino T, Hamada H. Adenovirus-mediated transfer of p53 and Fas ligand drastically enhances apoptosis in gliomas. Cancer Gene Ther 7, 732-738, 2000.
  85. Shinoura N, Yamamoto N, Yoshida Y, Asai A, Kirino T, Hamada H. Adenovirus-mediated transfer of caspase-8 in combination with superrepressor of NF-kappaB drastically induced apoptosis in gliomas. Biochem Biophys Res Commun 271, 544-552, 2000.
  86. Shinoura N, Muramatsu Y, Yoshida Y, Asai A, Kirino T, Hamada H. Adenovirus-mediated transfer of caspase-3 with Fas ligand induces drastic apoptosis in U-373MG glioma cells. Exp Cell Res 256, 423-433, 2000.
  87. Shinoura N, Ohashi M, Yoshida Y, Kirino T, Asai A, Hashimoto M, Hamada H. Adenovirus-mediated overexpression of Fas induces apoptosis of gliomas. Cancer Gene Ther 7, 224-232, 2000.
  88. Shinoura N, Yamamoto N, Yoshida Y, Fujita T, Saito N, Asai A, Kirino T, Hamada H. Adenovirus-mediated gene transduction of IkappaB or IkappaB plus Bax gene drastically enhances tumor necrosis factor (TNF)-induced apoptosis in human gliomas. Jpn J Cancer Res 91, 41-51, 2000.
  89. Shinoura N, Satou R, Yoshida Y, Asai A, Kirino T, Hamada H. Adenovirus-mediated transfer of Bcl-X(L) protects neuronal cells from Bax-induced apoptosis. Exp Cell Res 254, 221-231, 2000.
  90. Shinoura N, Muramatsu Y, Nishimura M, Yoshida Y, Saito A, Yokoyama T, Furukawa T, Horii A, Hashimoto M, Asai A, Kirino T, Hamada H. Adenovirus-mediated transfer of p33ING1 with p53 drastically augments apoptosis in gliomas. Cancer Res 59, 5521-5528, 1999.
  91. Asai A, Qiu J, Narita Y, Chi S, Saito N, Shinoura N, Hamada H, Kuchino Y, Kirino T. High level calcineurin activity predisposes neuronal cells to apoptosis. J Biol Chem 274, 34450-34458, 1999.
  92. Shinoura N, Yoshida Y, Asai A, Kirino T, Hamada H. Relative level of expression of Bax and Bcl-XL determines the cellular fate of apoptosis/necrosis induced by the overexpression of Bax. Oncogene 18, 5703-5713, 1999.
  93. Shinoura N, Yoshida Y, Nishimura M, Muramatsu Y, Asai A, Kirino T, Hamada H. Expression level of Bcl-2 determines anti- or proapoptotic function. Cancer Res 59, 4119-4128, 1999.
  94. Shinoura N, Yoshida Y, Tsunoda R, Ohashi M, Zhang W, Asai A, Kirino T, Hamada H. Highly augmented cytopathic effect of a fiber-mutant E1B-defective adenovirus for gene therapy of gliomas. Cancer Res 59, 3411-3416, 1999.
  95. Shinoura N, Ohashi M, Yoshida Y, Asai A, Kirino T, Saito I, Hamada H. Construction, propagation, and titer estimation of recombinant adenoviruses carrying proapoptotic genes. Hum Gene Ther 9, 2683-2689, 1998.
  96. Yoshida Y, Sadata A, Zhang W, Saito K, Shinoura N, Hamada H. Generation of fiber-mutant recombinant adenoviruses for gene therapy of malignant glioma. Hum Gene Ther 9, 2503-2515, 1998.
  97. Shinoura N, Yoshida Y, Sadata A, Hanada K, Yamamoto S, Kirino T, Asai A, Hamada H. Apoptosis by retrovirus- and adenovirus-mediated gene transfer of Fas ligand to glioma cells: implications for gene therapy. Hum Gene Ther 9, 1983-1993, 1998.
  98. Hara T, Kosaka N, Shinoura N, Kondo T. PET imaging of brain tumor with [methyl-11C]choline. J Nucl Med 38, 842-847, 1997.
  99. Shinoura N, Nishijima M, Hara T, Haisa T, Yamamoto H, Fujii K, Mitsui I, Kosaka N, Kondo T, Hara T. Brain tumors: detection with C-11 choline PET. Radiology 202, 497-503, 1997.
  100. Matsutani M, Sano K, Takakura K, Fujimaki T, Nakamura O, Funata N, Seto T. Primary intracranial germ cell tumor:a clinical analysis of 153 histologically verified cases. J Neurosurg 86, 446-455, 1997.
  101. Shinoura N, Chen L, Wani MA, Kim YG, Larson JJ, Warnick RE, Simon M, Menon AG, Bi WL, Stambrook PJ. Protein and messenger RNA expression of connexin43 in astrocytomas: implications in brain tumor gene therapy. J Neurosurg 84, 839-845, 1996.
  102. Matsutani M, Nakamura O, et al. Comparison of whole brain radiation therapy and locally limited radiation therapy in the treatment of solitary brain metastases from non-small cell lung cancer. Neurologia medico-chirurgica 36, 364-369, 1996.
  103. Fujii H, Kosuda S, Suzuki K, Yorino H, Akita S, Negishi H, Nakamura O, Shitara N, Kubo A. Usefulness of Ga-67 brain SPECT in patients with CNS malignant lymphoma. Ann Nucl Med 10, 391-394, 1996.
  104. Ueki K, Matsutani M, Nakamura O, Tanaka Y. Comparison of whole brain radiation therapy and locally limited radiation therapy in the treatment of solitary brain metastases from non-small cell lung cancer. Neuro Med Chir (Tokyo) 36, 364-369, 1996.
  105. Shinoura N, Paradies NE, Warnick RE, Chen H, Larson JJ, Tew JJ, Simon M, Lynch RA, Kanai Y, Hirohashi S, Hemperly JJ, Menon AG, Brackenbury R. Expression of N-cadherin and α-catenin in astrocytomas and glioblastomas. Br J Cancer 72, 627-633, 1995.
  106. Shinoura N, Shamraj OI, Hugenholz H, Zhu JG, McBlack P, Warnick R, Tew JJ, Wani MA, Menon AG. Identification and partial sequence of a cDNA that is differentially expressed in human brain tumors. Cancer Lett 89, 215-221, 1995.
  107. Shinoura N, Heffelfinger SC, Miller M, Shamraj OI, Miura NH, Larson JJ, De Tribolet N, Warnick RE, Tew JJ, Menon JJ. RNA expression of complement regulatory proteins in human brain tumors. Cancer Lett 86, 143-149, 1994.
  108. Yamada K, Kasama M, Kondo T, Shinoura N, Yoshioka M. Chromosome studies in 70 brain tumors with special attention to sex chromosome loss and single autosomal trisomy. Cancer Genet Cytogenet 73, 46-52, 1994.
  109. Kosuda S, Fujii H, Aoki S, Suzuki K, Tanaka Y, Nakamura O, Shitara N. Prediction of survival in patients with suspected recurrent cerebral tumors by quantitative thallium-201 single photon emission computed tomography. Int J Radiat Oncol Biol Phys 30, 1201-1206, 1994.
  110. Matsutani M, Nakamura O, Nakamura M, Nagashima T, Asai A, Fujimaki T, Tanaka H, Ueki K, Tanaka Y. Radiation therapy combined with radiosensitizing agents for cerebral glioblastomas in adults. J Neurooncol 19, 227-237, 1994.
  111. Nakamura O, Matsutani M, Shitara N, Okamoto K, Kaneko M, Nakamura H, Asai A, Ueki K, Shimizu T, Tanaka Y, et al. New treatment protocol by intra-operative radiation therapy for metastatic brain tumours. Acta Neurochir (Wien) 131, 91-96, 1994.
  112. Matsutani M, Nakamura O, Nagashima T, Asai A, Fujimaki T, Tanaka H, Nakamura H, Ueki K, Tanaka Y, Matsuda T. Intra-operative radiation therapy for malignant brain tumors: rationale, method, and treatment results of cerebral glioblastomas. Acta Neurochir (Wien) 131, 80-90, 1994.
  113. Fujimaki T, Matsutani M, Funada N, Kirino T, Takakura K, Nakamura O, Tamura A, Sano K. CT and MRI features of intracranial germ cell tumors. J Neurooncol 19, 217-226, 1994.
  114. Kosuda S, Nakamura O, et al. Reassessment of quantitative thallium-201 brain SPECT for miscellaneous brain tumors. Nuclear Medicive 7, 257-263, 1993.
  115. Shinoura N, Dohi T, Kondo T, Yoshioka M, Takakura K, Oshima M. Ganglioside composition and its relation to clinical data in brain tumors. Neurosurgery 31, 541-549, 1992.
  116. Oikawa T, Nakamura O, et al. Inhibition of angiogenesis by staurosporine, a potent protein kinase inhibitor. The Journal of Antibiotics 45, 1155-1160, 1992.
  117. Kawashima I, Tai N, Nakamura O, et al. Antibody responses to Ganglioside-series gangliosides in different strains of inbred mice. Molecular Immunology 29, 625-632, 1992.
  118. Kosuda S, Aoki S, Suzuki K, Nakamura H, Nakamura O, Shidara N. Primary malignant lymphoma of the central nervous system by Ga-67 and Tl-201 brain SPECT. Clin Nucl Med 17, 961-964, 1992.
  119. Fujimaki T, Matsutani M, Nakamura O, Asai A, Funada N, Koike M, Segawa H, Aritake K, Fukushima T, Houjo S, et al. Correlation between bromodeoxyuridine-labeling indices and patient prognosis in cerebral astrocytic tumors of adults. Cancer 67, 1629-1634, 1991.
  120. Nakamura O, Iwamori M, Matsutani M, Takakura K. Ganglioside GD3 shedding by human gliomas. Acta Neurochir (Wien) 109, 34-36, 1991.
  121. Oikawa T, Nakamura O, et al. Inhibition of angiogenesis by vitamin D3 analogues. European Journal of Pharmacology 178, 247-250, 1990.
  122. Asai A, Matsutani M, Kohno T, Nakamura O, Tanaka H, Fujimaki T, Funada N, Matusda T, Nagata K, Takakura K. Subacute brain atrophy after radiation therapy for malignant brain tumor. Cancer 63, 1962-1974, 1989.
  123. Oikawa T, Nakamura O, et al. Inhibition of angiogenesis by bleomycin and its copper complex. Chem Pharm Bull 38, 1790-1792, 1990.
  124. Maruo Y, Nakamura O et al. Responsiveness of subcutaneous human glioma xenografts to various antitumor agents. Anticancer Research 10, 209-212, 1990.
  125. Oikawa T, Nakamura O et al. A highly potent antiangiogenic activity of retinoids. Cancer Letters 48, 157-162, 1989.
  126. Nakamura O et al. rCBF in brain tumours as measured by xenon enhanced CT. Neurological Research 9, 24-29, 1987.
  127. Nakamura O et al. Interactions of human fibroblast interferon with chemotherapeutic agents and radiation against human gliomas in nude mice. Neurological Research 8, 152-156, 1986.
  128. Segawa H, Wakai S, Tamura A, Yoshimasu N, Nakamura O, Ohta M. Computed tomographic measurement of local cerebral blood flow by xenon enhancement. Stroke 14, 356-362, 1983.